Neonatal Graves’ Disease and Cholestatic Jaundice: Case Series and Review of the Literature
نویسندگان
چکیده
Cholestatic jaundice and elevated liver enzymes are uncommon, but recognized, manifestations of neonatal thyrotoxicosis. Current guidelines for evaluation of cholestatic jaundice and reviews in Neonatology literature do not discuss hyperthyroidism in the differential diagnosis of cholestatic jaundice. We report two cases of neonatal thyrotoxicosis secondary to neonatal Graves’ disease that presented with cholestatic jaundice and elevated liver enzymes at birth. Early recognition of thyrotoxicosis as a cause of the hepatic disease in the neonate is crucial to prevent unnecessary diagnostic procedures and to initiate timely treatment.
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Intrahepatic cholestasis in the newborn.
Hitherto little attention has been paid to cholestatic jaundice in the newborn which occurs in the absence of rhesus incompatibility. 4 such cases, among a consecutive series of 24 newborns with prolonged neonatal jaundice occurring in the Devon and Exeter clinical area since 1960, are here described in detail to demonstrate that their clinical and histological picture, and their prognosis, is ...
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